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forty four Additionally, anergic cells Typically keep the next susceptibility to apoptosis Except if anti-apoptotic proteins such as BCL2 are overexpressed, as is the situation for CLL cells.45 Indeed, most significant therapeutic advancements developing in the last decade are linked to the inhibition of BCR and BCL2-mediated signaling.
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forty eight These translocations may possibly occur from the context of sophisticated karyo forms. The most common rearrangements involve 13q14, with numerous associates, as well as the IGH locus. The genes most commonly rearranged with IGH are BCL2
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